Structural features for α-galactomannan binding to galectin-1
نویسندگان
چکیده
منابع مشابه
Structural aspects of binding of α-linked digalactosides to human galectin-1.
By definition, adhesion/growth-regulatory galectins are known for their ability to bind β-galactosides such as Galβ(1 → 4)Glc (lactose). Indications for affinity of human galectin-1 to α-linked digalactosides pose questions on the interaction profile with such bound ligands and selection of the galactose moiety for CH-π stacking. These issues are resolved by a combination of (15)N-(1)H heteronu...
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Carsten Reissner, Johanna Stahn, Dorothee Breuer, Martin Klose, Gottfried Pohlentz, Michael Mormann, and Markus Missler From the Institute of Anatomy and Molecular Neurobiology, Westfälische Wilhelms-University, Vesaliusweg 2-4, 48149 Münster, Germany; Institute of Medical Physics and Biophysics, Westfälische Wilhelms-University Robert-Koch Strasse 31, 48149 Münster, Germany Cluster of Excellen...
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Galectins are a growing family of animal lectins with common consensus sequences that bind beta-Gal and LacNAc residues. There are at present 14 members of the galectin family; however, certain galectins possess different structures as well as biological properties. Galectin-1 is a dimer of two homologous carbohydrate recognition domains (CRDs) and possesses apoptotic and proinvasive activities...
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Ras biological activity necessitates membrane anchorage that depends on the Ras farnesyl moiety and is strengthened by Ras/galectin-1 interactions. We identified a hydrophobic pocket in galectin-1, analogous to the Cdc42 geranylgeranyl-binding cavity in RhoGDI, possessing homologous isoprenoid-binding residues, including the critical L11, whose RhoGDI L77 homologue changes dramatically on Cdc42...
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OBJECTIVE Recent studies have demonstrated that galectin-1 (Gal-1) and galectin-3 (Gal-3) can bind von Willebrand factor and directly modulate von Willebrand factor-dependent early thrombus formation in vivo. Because the glycans expressed on human factor VIII (FVIII) are similar to those of von Willebrand factor, we investigated whether galectins might also bind and modulate the activity of FVI...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 2011
ISSN: 1460-2423,0959-6658
DOI: 10.1093/glycob/cwr173